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This Second Amendment having an effective date of October 24, 2016 (the “Second Amendment”) amends the Scientific and Technical Collaboration Agreement (“Agreement”) entered into between Agilent Technologies, Inc., hereinafter “AGILENT INC” and the São Paulo Research Foundation, hereinafter "FAPESP", hereinafter collectively referred to as the “Parties”, on August 29, 2011 (the “Agreement”).

Whereas the Parties desired to enter the Agreement under which the Parties selected and funded Research Projects, all pursuant to the terms and conditions set forth in the Agreement;

Whereas through this Second Amendment, the Parties desire to provide supplemental equal funds to support additional research, in accordance with the Agreement;

Whereas the Parties wish to extend the scientific and technical collaboration provided for in the Agreement;

Now, therefore, the Parties hereby agree to amend the Agreement in writing and as follows:

A new Section 3.1.2 is inserted and Section 5.1 is replaced as follows:

3.1.2 Financial support for first extension . Additional financial support for the projects selected under this Agreement will encompass a total of the equivalent of one hundred thousand US dollars ($100,000 USD) in Brazilian Reais from FAPESP and one hundred thousand US dollars ($100,000 USD) from AGILENT INC. Agilent will transfer its portion of the funding to FAPESP within six months of the date of this Amendment.

5.1 Term . Unless earlier terminated pursuant to this Section 5, the term of this Agreement will commence on the Effective Date of the Agreement, and remain in effect until five (5) years after the effective date of the Second Amendment (the "Term"). Any payment made by AGILENT INC. of supplemental funds to support additional research under this Agreement and the effect of extending the expiration date of this Agreement will be accepted by FAPESP if an amendment to this Agreement is signed by both parties.

In all other respects, the Agreement shall remain unchanged and in full force and effect.

IN FULL AND MUTUAL AGREEMENT, this Amendment is signed and the contents thereof translated in Portuguese language.

Original of Amendment signed ________________________.